Alz Well That Endz Well

"Everything will be all right in the end. So if it is not all right, then it's not yet the end!"

--Sonny Kapoor (Dev Patel's character), The Best Exotic Marigold Hotel (2011)

A great outlook if You happen to have all the time in the world(z), like our asymptotic high-stepping ant.

The rest of us must learn to take short cuts or even resort to shear magic to make it appear as such.

In one isolated case, reach deep to grasp victory from the jaws of defeat (or vice versa; okay, I won't spare you--from complete, utter ruin and annihilation).

So, here we go...


You Say Alzheimer's and I say Tri-Ethylene Carbo(xy)/(Cyclo)-Hydro(carbon/Heptane/Hexane), that's just by word association and want of a Hi-TECH solution to an Old Age problem.

Don't all run out and try it on each other or something like this might happen. And Nobody wants that, believe me, I Am Nobody.

The first method is by word analysis:
Alz Heimer--

• The Alz River in Germany derives from the old Indo-European root for 'swamp' (from the Norse meaning, 'marsh' or 'spongey') and 'alder' (the tree, copse), meaning that river runs through or originates from such. 
• From other roots, it is similar to words meaning 'old', 'elder' or 'ancient'.
• The noun Heim(e), from the German word for 'home' or 'homes', 'homeward', and the understanding that the -r at the end of Heimer makes it masculine.

The psychiatrist to first describe the atrophy associated with the disease and the dementia associated with it being Alois Alzheimer.

It should come as no big surprise that tissue samples from brains of patients suffering from Alzheimer's Disease do appear 'spongey' from the cumulative affect of chronic immune activation due to the inflammatory reaction to senile plaques (amyloid beta peptide) and hyperphosphorylation of tau proteins (see Coral Reef/Brain Analogy), or tau inclusions that result from self-assembly of tau tangles. (The 'spongy' description based on the physician's name associated with the disease may mean that it shares some common characteristics with Spongiform encephalopathy, or 'mad cow disease' where prions are implicated, 'improper folding of proteins' absent any type of bacterial or viral infection).

The binding domains of tau proteins are located at carboxy-terminus that are positively (+) charged, allowing bonding to (-) negatively charged microtubules.

This enables self-assembly of the tau inclusions, another way of saying a matrix or lattice is formed due to the reduced Gibbs free energy state from forming such a structure.

Classically, such self-assembly is spontaneous and reversible, since it is associated with non-covalent bonding.


Summarily, His surname in the modern vernacular means "old-school."

And since I am still left here spinning my wheels (on the bus), so to speak, I have nothing to do today but channel Luqman.

Some things the Quran mentions about getting old and old age:


2:266 About Gardens, watering & Old Age
Surah 2 Al.Baqara  الم
أَيَوَدُّ أَحَدُكُمْ أَن تَكُونَ لَهُ جَنَّةٌ مِّن نَّخِيلٍ وَأَعْنَابٍ
تَجْرِي مِن تَحْتِهَا الأَنْهَارُ
 لَهُ فِيهَا مِن كُلِّ الثَّمَرَاتِ وَأَصَابَهُ الْكِبَرُ
وَلَهُ ذُرِّيَّةٌ ضُعَفَاء
 فَأَصَابَهَا إِعْصَارٌ فِيهِ نَارٌ
فَاحْتَرَقَتْ
كَذَلِكَ يُبَيِّنُ اللّهُ لَكُمُ الآيَاتِ لَعَلَّكُمْ تَتَفَكَّرُونَ (2:266

2:266 Would any of you wish to have a garden of palms and grapes (or jujubes)
running beneath it rivers
for them in it every fruit and is afflicted with old age (grows old, enlarged)
and has weak/impaired/feeble/impotent/debilitated  seeds/offspring/generation/lineage
(causing) being stricken/hit/suffer a surging/twister/tornado within it fire/flame/heat/light/flare
(causing it) to burn
In this manner God Shows/Evinces/Reveals to you the Signs so that you would consider/understand/think/reflect...


14:39 About God's Blessing to Ibrahim in His Old Age
Surah 14 Ibrahim الَر
الْحَمْدُ لِلّهِ الَّذِي وَهَبَ لِي عَلَى الْكِبَرِ إِسْمَاعِيلَ وَإِسْحَقَ إِنَّ رَبِّي لَسَمِيعُ الدُّعَاء (14:39
14:39) (Ibrahim Said), "All Praise Be To God Who Bestowed (Gave Away, Proffered) Upon Me In Old Age Isma3eal and Ishaak, for Indeed My God (Sustainer) Hears Supplications (Hears/Responds to  Prayers)"

15:54 About glad tidings in old age
Surah 15 Hijr  الَر
قَالَ أَبَشَّرْتُمُونِي عَلَى أَن مَّسَّنِيَ الْكِبَرُ فَبِمَ تُبَشِّرُونَ (15:54
15:54) He Said, "You Give me Glad Tidings (Bestowal, Blessing of a child) ...? Indeed, in my old age (years advanced) for what You Proffer upon me!

17:23 How to treat elderly parents
Surah 17 Al.Isra (The Ascension, The Night Journey)
وَقَضَى رَبُّكَ أَلاَّ تَعْبُدُواْ إِلاَّ إِيَّاهُ
وَبِالْوَالِدَيْنِ إِحْسَانًا
إِمَّا يَبْلُغَنَّ عِندَكَ الْكِبَرَ أَحَدُهُمَا أَوْ كِلاَهُمَا
فَلاَ تَقُل لَّهُمَآ أُفٍّ
وَلاَ تَنْهَرْهُمَا
 وَقُل لَّهُمَا قَوْلاً كَرِيمًا (17:23
17:23 And Your Lord (God, Sustainer) Ordains (Requires) that you worship none other than He; and Charity toward (your) Parents;
Should (either) they reach old age while they are with you, one of them or all of them;
Do not say to them, "Fie" (be contemptible)
And do not berate them (make them 'collapse')
And speak to them in a kindly manner (gracious, honorable words).

19:8 About infermity and old age
Surah 19 Maryam (Mary, Mother of Jesus)
قَالَ رَبِّ أَنَّى يَكُونُ لِي غُلَامٌ وَكَانَتِ امْرَأَتِي عَاقِرًا وَقَدْ بَلَغْتُ مِنَ الْكِبَرِ عِتِيًّا (19:8
19:8) He Said, "My God, indeed I shall have a young soul (a child) when my wife is barren and I am infirm (literally from  the root عته, dementia, senility) from old age?

36:68 About growing old
Surah 36 Ya.Seen (يس)
وَمَنْ نُعَمِّرْهُ نُنَكِّسْهُ فِي الْخَلْقِ أَفَلَا يَعْقِلُونَ (36:68
36:68) And whomever We Age (let grow old), We Reduce them in Creation (الْخَلْقِ  make, fiber, creation); Do you not understand? (var. 'causing them to not understand')


As duality is found everywhere in the natural world in order to Teach, Compare, and Contrast and the Quran makes no secret of the fact that God does not do the least harm to Its Creatures (Creation), then it stands to reason that if they hurt each other and themselves, that duality is meant to serve to their benefit.

So, if Alzheimer Disease is prevalent in a society (numbers are suspect, something like 10% in the United States population vs. 1% in South Asia (India), which means just about the same number of people in each population) then there is a de facto remedy already at hand.

The first cut to find one, in the most elementary attempts, would be a direct word-for-word analysis. Hey, it's your language, not mine. Remember? I'm the alien.

So an old-school disease can be cured (or at least treated) with a hi-tech solution, its etymological dual (in this case we are looking for the opposite).

The word TECH, (short for technology), is also an anagram for somethings we find in the Chemical Abstracts list.

My take on it: Tri-Ethylene Carbo(xy)/or Cyclo-Hydro(carbon/Heptane/Hexane).

And a deep understanding of the geometry of the chemistry and biochemistry can help refine it.

I'll see what I can do in one afternoon, an expert in the field can and will do better.

Seeing how desperation can drive some of you out there to justify some of this here, I have to preface everything here with a cautionary tale--Do Not put it all in a can of air freshener and expose the population at large--that's the end of the story.

Chances are the better approach is to use something that can breach the blood-brain barrier, and try it on a happy well-cared for lab rat rather than a school of K-6 grade students or other unsuspecting volunteers (aka victims).

The method is to use a derma-patch with the investigative 'drug' (aka 'toxin') and look for onset of sensitization (direct inspection of the skin area and/or EEG).

The EEG should show some early onset of the efficacy if any type of slowing or variant is present from baseline brain activity.

Once sensitized, it would serve better to dose via inhalants and get better control of the dosage (tied into the olfaction/memory experience via amygdala/hippothalmus/limbic system--a way around the blood-brain barrier). The idea is to cause or force the brain tissue to re-generate--in all likelihood (and speaking from direct experience) it's gonna hurt (euphemism for WTF!JRQ@P%P) .

Since it is the brain under discussion, some altruistic rat's, but a brain, nevertheless, the signaling that is going to be interrupted due to the tissue damage has to be re-routed (re-established) and brains have a plasticity which allows for that.

Conceivably, since humans only use less than 10% of their brains anyway, there should be enough real estate available to supplant the lost utility from diseased tissue:

1. until it heals or 
2. new tissue is generated or 
3. the signaling is rerouted (http://cnx.org/content/m10177/latest/?collection=col10048/latest)
4. or any combination of the above

So, environmental stimulation is a major part of both the treatment and the recovery; activities that engage the higher-level 'thinking' processes, since my understanding is that Alzheimer's rarely affects the medulla. And since the subjects' emotional experience is affected, there will be catastrophic changes in their perception--hopefully they get lucky and can find someone who can relate to that, and not just some psychoanalyst worrying about picking their kids up from school in time if the session runs 5 minutes over.

(ref medulla, pith,*metals/aluminum/central part/shaft vs. tau proteins + microtubules//plant anology== http://apageinthelife.blogspot.com/2011/07/disengagement.html)

The geometry/branching of the neurons associated with these types of brain cells/nuerotransmitters may indicate their inclusion in movement-related vs. cognition-affected morbidity:

Principle Cell Types in the Cerebellum
Including Purkinje Cells,
Basket Cells,
Moss Fibre and
Nueroglia

For refining the idea, the approach it to see what is clinically successful to-date.

Not having access to the medical research, the current published material found at the Malibu Public Library (limited at best) seems to indicate that there is a body of evidence that dietary regulation is promising in at least delaying the onset of the disease.

Since the treatment requires a 2-prong approach, anti-inflammatory and anti-oxidation, foods rich in the following are essential to good brain health:

1. Vitamin C

Vitamin C

• In humans, vitamin C is a highly effective antioxidant, acting to lessen oxidative stress and an enzyme cofactor for the biosynthesis of many important biochemicals. Vitamin C acts as an electron donor for important enzymes, i.e., acts as a reducing agent, donating electrons and preventing oxidation to keep iron (Fe) and copper (Cu) atoms in their reduced states.
• Reducing transition metals means cupric ions (Cu2+) to cuprous (Cu1+), and ferric ions (Fe3+) to ferrous (Fe2+): 
• Surah 17 Al.Isra (The Night Journey, The Ascension)
• قُل كُونُواْ حِجَارَةً أَوْ حَدِيدًا (17:50  
• (17:50) Say, "Whether you be Stones (see petrachor below) or Iron..." (God Resurrects you...)
• Surah 18 Al.Kahf (The Cave)
• آتُونِي زُبَرَ الْحَدِيدِ 
• حَتَّى إِذَا سَاوَى بَيْنَ الصَّدَفَيْنِ
• قَالَ انفُخُوا حَتَّى إِذَا جَعَلَهُ نَارًا
•  قَالَ آتُونِي أُفْرِغْ عَلَيْهِ قِطْرًا (18:96
•  (18:96) (Dul Qrnain) Said, "Give Me (Bring Me) Iron (Fe) pieces (filings/tailings/particles), until/even/while if/whether I even/equalize/make/form between the ssdfeenat 'nacreous' (literally, the root word having to do with pearly, testaceous, scalloped, and ' بالغ النفاسة' an indiomatic phrase meaning 'priceless' but breaks down to 'an adult/advanced form of itself/selfsame'; the word traditionally translated to mean 'mountain sides')." He Said, "Blow/Insufflate (use bellows, to heat and purify) until/even if it becomes/creates a glow/blaze/fire/heat..." He Said, "Give Me (Bring Me)..قِطْرًا 'qtran' .to empty/drain/terminate/pour/vacate/desiccate over it/upon it drops/trickle/dribble (like quench it)"

{The chemistry of this thing in 18:96: Dhul Qarnain is basically saying

1. 'give me  pieces of Iron until I even
2. (equalize) the sdffeenat (scalloping like gullies between mountain sides or has properties that are shell-like formed from advanced/aged/adult form of self-similars;
3. then blow (like a bellows would, and an act of insufflation that basically purifies) until it heats up to a 'glowing' state; 
4. then quench by dribbling or pouring over it  قِطْرًا 'qtran' a desiccate, sometimes to encapsulate it and passivate the process....'

--As for the snide remark 'get in there and do it yourself rather than the comfort of your armchair' the short answer is "if that was meant to be, You would not have marginalized my credibility to such an extent that I am nothing but a crazy mother!"---Besides, don't give me guff for rendering aid gratis, at this point I still haven't got paid. And just how comfortable do You think i am in public places like libraries and coffee shops?

}

• Surah 22 Al.Hajj (The Pilgrimage)
• وَلَهُم مَّقَامِعُ مِنْ حَدِيدٍ (22:21 
• (22:21)  They have Iron hooks (hooked rods); They get/have hooked rods of iron
• This may be an allusion to the 'shape' of the bond, something like this is related to acetic acid dimers?

• Surah 57 Al.Hadid (Iron)
• لَقَدْ أَرْسَلْنَا رُسُلَنَا بِالْبَيِّنَاتِ 
• وَأَنزَلْنَا مَعَهُمُ الْكِتَابَ وَالْمِيزَانَ 
• لِيَقُومَ النَّاسُ بِالْقِسْطِ 
• وَأَنزَلْنَا الْحَدِيدَ فِيهِ بَأْسٌ شَدِيدٌ 
• وَمَنَافِعُ لِلنَّاسِ
•  وَلِيَعْلَمَ اللَّهُ مَن يَنصُرُهُ وَرُسُلَهُ بِالْغَيْبِ
•  إِنَّ اللَّهَ قَوِيٌّ عَزِيزٌ (57:25
• (57:25)   We Send Our Messengers with Illucidations (Clarifying Signs)
• and Propagated/Revealed with them the Book and the Scales (of Justice)
• to the Community of People In Truth (var. So that People May Account/Judge Equitably/In Truth)
• And We Sent Down Iron with Biting Strength (alt. sinuous pith, intense sturdiness/pith/hardiness, quite strong);
• and is useful/beneficial to people.
• And so that God Discerns/Knows those who champion Him and His Messenger(s) Unseen (Faithfully, without knowing, unbeknownst to them);
• Indeed, God is All-Powerful, Beloved.

• (57:25) ...in context of forming a molecule, 'sent down Iron' means 'Reduced Iron'...generally reduction of Iron is done in the presence of ash or soda, in other words Carbon...whether it be in forging steel (o, yeah, how else do you think David (pbuh) learned to make armor?) or re-aligning body chemistry to healthy levels, this process overall, is meant to be beneficial to humanity.

• Some scientists have suggested that loss of the vitamin C biosynthesis pathway may have played a role in rapid evolutionary changes, leading to hominids and the emergence of human beings. 
• Limited studies in men's health seem to indicate Vitamin C contributes to an increase in life expectancy.

2. Vitamin E

One of the 8 forms of Vitamin E

• Vitamin E has many biological functions, it is known to serve an antioxidant function.
• Other functions include enzymatic activities, gene expression and neurological function(s).
• It is suggested that the most important function of vitamin E is in cell signaling (and, that it may not have a significant role in antioxidant metabolism).

3. Polyphenols

Neutral phenol substructure "shape".
An image of a computed electrostatic surface of neutral phenol,
showing neutral regions in green,
electronegative areas in orange-red,
and the electropositive phenolic proton in blue.

• The most abundant polyphenols are the condensed tannins, found in virtually all families of plants, and comprising up to 50% of the dry weight of leaves. 
• Plant polyphenols have antioxidant action. 
• In other words drink green tea.

4. Selenium

• Selenium is an essential micronutrient in animals but is toxic in large doses.
• Selenium is a nonmetal, chemical element with symbol Se and atomic number 34 with properties that are intermediate between the elements Sulfur and Tellurium. 
• Selenium (Greek σελήνη selene meaning Moon) was discovered in 1817 by Jöns Jakob Berzelius, who noted its similarity to the previously-known Tellurium (Te, named for the Earth).
• Selenium is a component of the unusual amino acids selenocysteine and selenomethionine.
• In humans, selenium is a trace element nutrient that functions as cofactor for reduction of antioxidant enzymes, such as glutathione peroxidases and certain forms of thioredoxin reductase.
• Selenium also plays a role in the functioning of the thyroid gland and in every cell that uses thyroid hormone, by participating as a cofactor for the 3 of the 4 known types of thyroid hormone deiodinases, which activate and then deactivate various thyroid hormones and their metabolites.
• Selenium may inhibit Hashimoto's disease, in which the body's own thyroid cells are attacked as alien (auto-immune disease). A reduction of 21% on TPO antibodies was reported with the dietary intake of 0.2 mg of selenium.
• Selenium shows evidence of reducing the effects of mercury toxicity.
• Selenium deficiency is rare in healthy, well-nourished individuals. 
• Selenium deficiency can occur in patients with severely compromised intestinal function, those undergoing total parenteral nutrition, and in those of advanced age (over 90). 
• Selenium deficiency (as defined by less than 60% of normal) only occurs when a low selenium status is linked with an additional stress, such as high exposures to mercury (Hg) or as a result of increased oxidant stress due to vitamin E deficiency.
• There are interactions between selenium and other nutrients, such as Iodine and Vitamin E. 
• In other words, Eat nuts (Brazil nuts are rich in Selenium), cereals, meat, mushrooms, fish, and eggs.
• Do Not exceed the tolerable upper intake level of 400 micrograms per day.

5. β-Carotene

Beta-Carotene

• Carotenes are red/orange/yellow plant pigments that contain no oxygen.
• Beta-carotene is an antioxidant and is a form of carotin, a term used for several related unsaturated hydrocarbon molecules with 40 Carbon atoms and are synthesized by plants (terpenes) but cannot be made by animals. 
• β-Carotene can be stored in the liver and body fat and converted to retinal as needed,  making it a form of vitamin A for humans.
• The two ends of the β-carotene molecule are structurally identical β-rings--the group of nine carbon atoms at each end of the molecule.
• A study using 50 mg of β-carotene every other day prevented cognitive decline in a study of over 4000 physicians at a mean treatment duration of 18 years.
• Oral β-carotene provides some relief from photosensitivity (light sensitivity is a migraine trigger).
• The α-carotene molecule has a β-ring at one end and has been used in studies that show positive correlation to significantly reducing risk of death.

6. Curcumin

Curcumin
-enol and -keto forms

• Curcumin is a class of natural phenols that give turmeric its yellow color.
• Turmeric is a spice use extensively in Indian foods and is a member of the ginger family (Zingiberaceae) and historically has been used in Indian Ayurvedic medicine. (It is a home remedy for migraine headache relief).
• Curcumin can exist in several tautomeric forms, including a 1,3-diketo form and two equivalent enol forms.
• The enol form is more energetically stable in the solid phase and in solution.
• Preclinical studies suggest curcumin may be useful for the prevention and treatment of several diseases, however its effectiveness of has not yet been proven. It is indicated to:
• provide relief equivalent to ibuprofen for pain associated with osteoarthritis
• is known to inhibit blood clotting
• may be anti-carcinogenic
• known to aggravate gallstone problems
• has an effect on amyloid beta plaque build up, a major cause for Alzheimer’s, as an anti-inflammatory that affects the neuro-inflammatory cascade in neurotic plaque pathogenesis. 
• The study demonstrated that both low and high doses of curcumin reduce β-amyloid plaque buildup. 
• The study with low doses of curcumin demonstrated that there was a 32% reduction in insoluble plaque buildup that was treated with the spice and a 43% reduction in soluble plaque. 
• The effect is similar to that of aspirin, which is also said to suppress development of β-amyloid plaque buildup.
• low concentrations of curcumin can interfere with Herpes simplex virus-1 (HSV-1) replication
• Numerous studies have demonstrated that curcumin has a positive effect on neurogenesis in the hippocampus and increases the levels of brain-derived neurotrophic factor (BDNF) in rats:
• effective in protecting against toxicity and spatial memory impairment induced by amyloid β-protein infusion in a rat model
• curcumin diminished plaque burden and overall inflammation, but it also increased plaque-associated inflammatory cells suggesting enhanced clearance
• shrank the size of plaques and reduced neurite dystrophy in an Alzheimer mouse model
• has a synergistic effect with fish oil to protect against cognitive deficits in a transgenic rodent model
• A curcumin pyrazole derivative identified by high throughput screening was found to improve memory and was broadly neuroprotective, stimulating BDNF in vitro and in vivo and found to be protective in animal models of brain trauma and stroke.
• The results of studies in rodents may not translate to humans. It is said that in humans, unlike rats, curcumin is extensively metabolized to the glucuronidated form, which does not penetrate the blood–brain barrier and is therefore unable to reach brain tissues.
• It may be synthesized with cinnamic acid as the start molecule.
• In other words, curry is good for you.

7. Cinnamic Acid

Cinnamic Acid

• A white, crystallin organic acid naturally found in cinnamon, balsams, or shea butter (an extract from the African shea tree nut).
• Is also manufactured synthetically in the pharmaceutical industry.
• Slighly soluble in water, freely soluble in benzene, diethyl ether and acetone, and insoluble in hexane.
• Primarily used in flavoring and manufacturing esters in the perfume industry.
• Used as a building block molecule in curcumin synthesis.

Add to this the fact that South Asian (India) diets are rich in fruits and vegetables (anti-oxidants) and less saturated fats and the spices turmeric and cinnamon, the supplements curcumin and cinnamic acid round out the list.

Too much effort? I know.

If it were me I would drink Vinegar with the Veil of the Mother of Vinegar all day long and just be done with it, but Americans require a little more finesse (and an explanation).

Why? O, You want a reasonable explanation, anyway?

Frankly, because the whole thing reeks of toxic liver syndrome.

The conclusion follows from the following facts:

1. There are said to be genetically predisposed individuals in the population; chromosome 19 and the associated apoliproteins genotypes: APOE e2, APOE e3, and APOE e4, the APOE e4 found in 1/2 of the Alzheimer population. 
• That leaves the other half having no genetic basis (gene map locus 19q13.2) for developing the disease--basically, a statistical wash (it would mean that genotype is just as unlikely as it is likely to play any role at all).
2. There is a disproportionate number of women in the Alzheimer population than men, and American women in general seem to field more stress than their male counterparts.
• The liver produces cortisol in response to stress--fight-or-flight mechanism.
3. Individuals with Alzheimers typically have some medically significant flag for hypertension, elevated cholesterol, and/or obesity.
4. Individuals with relatives that have the disease are 18% more likely to develop it than those in the general population who do not (only 4% chance), but of those how many actually have the apoliprotein E and of those how many are predisposed due to other family-related health conditions exacerbated by their lifestyle choices--are sedentary, have poor nutrition, suffer from high-blood pressure, are obese, are stressed out, and have high cholesterol?
5. There is weighty evidence that the disease can be delayed or altogether avoided with proper nutrition, and typically individuals who are careful of their nutrition tend to live healthier lifestyles that circumvent such things as high blood pressure, high cholesterol, and obesity.
6. The liver is the primary organ involved in removing toxic waste from the body, including that produced from inefficient respiration (the oxidation process in the body on a cellular level)--the very reason why anti-oxidants seem to play a role in treating the symptoms.
7. The brain is basically fatty tissue and the liver handles body fat.

All of the above considerations taken as a set scream bad, bad liver.

A first course of action is prevention, and holistic approaches to liver cleansing. Most liver cleansing protocols employ acidic juices from lemons or apple juice and flush with buffered solutions of cola/soda (buffer) and olive oil, the less refined approach would be to drink the apple cider vinegar (contains acetic acid CH3COOH) with the veil of the mother of vinegar (as an anti-oxidant to scavenge the oxygen from inefficient mitochondrial respiration. Simplistic? So what!)

Biochemistry 

At physiological pHs, acetic acid is usually fully ionized to acetate. In biochemistry, acetate and acetic acid are equivalent.

The acetyl group, derived from acetic acid, is fundamental to all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats. Unlike longer-chain carboxylic acids (the fatty acids), acetic acid does not occur in natural triglycerides. 

Acetic acid is produced and excreted by acetic acid bacteria, notable ones being the Acetobacter genus and Clostridium acetobutylicum. These bacteria are found universally in food stuffs, water, and soil, and acetic acid is produced naturally as fruits and other foods spoil. Acetic acid is also a component of the vaginal lubrication of humans and other primates, where it appears to serve as a mild antibacterial agent.

No longer a chemical guru, but just recalling a smattering of the overall process that cumeric synthesis to phenolic type cumene by oxidation, and that polyphenols in the diet mitigate Alzheimer's also points to some kind of failure in the efficacy of the liver function.

So what this post is about is having missed all preventative measures and now a loved one has been diagnosed, too late, with advanced stages of Alzheimer's, we are going to try and rebuild their brain.

to be continued...

But while the thought is fresh in my mind (not quite Alzheimer, but somewhat senile nevertheless) the association with 'swamp' may provide more clues about the nature of the disease.

There are several causes hypothesized to contribute to the onset and progression of Alzheimer's: cholinergic (see acetylcholine + acetic acid + vinegar), amyloid, tau, and others.

A swamp is a low-lying area of uncultivated ground where water collects; it is seasonally flooded (intermittently fully or partially covered with water) bottomland that is dominated by woody vegetation. It has better drainage than a bog and more woody plants than a marsh.

What is known of AD as of this writing (December 27, 2012) is that AD primarily affects synapses and the cerebral cortex (the outer-most neural tissue of the cerebrum), which develops from the most anterior part of the neural plate--a specialized part of the embryonic ectoderm, and explains why any kind of brain sensitization (ie., breaching the blood-brain barrier) must start with skin sensitization, see above.

{
You know, Francis, I really could do without your 'powjr0q2' pity! You want Peace?
Get out of my way!

But, thanks for your suggestion: THC can also be pronounced 'tech' --the cannabinoid substance found in marijuana which is also known to help mitigate AD symptoms.
}

The neural plate folds and closes to form the neural tube and from within this cavity the ventricular system develops, and from the epithelial cells of its walls the neurons and glia of the nervous system gives rise to the cerebral hemispheres and cortex. (Recently,  my daughter recommended I watch 'Food Matters', and in Feb. 2013 I got around to viewing it. One of the presenters in the documentary, a certified nutritionist, was adamant that damage to epithelial cells in the human body cannot only be avoided with proper nutrition (food alone) but that they can be repaired and healthy regrowth encouraged. His cross to bear is that he has drummed that matra for the better part of 40 years in his career, but since it is not a real money maker to simply eat right, his message is drowned out by the medical vanguard--$1 for a bunch of carrots vs $750 for a month's supply of pills--go figure!)

The fact that the neocortex develops from this 'inside-out' manner makes 'bottomland' or 'low-lying area' a convenient analogy to the ventricular system as the 'swamp'. This is bolstered by the fact that the ventricular system itself does not contain the more cultivated 'brain' cells, (ie., it is uncultivated since brain cells are not found within it).

Adding to the analogy is the fact that the ventricular system contains the cerebrospinal fluid in the brain and is continuous with the central canal of the spinal cord. The cerebrospinal fluid gives us the metaphor for the 'seasonal' or 'intermittent' flooding, and the 'central canal' (ie., spinal chord) provides a ready analogy to the Alz River itself.

{Further Analogies About the Brain and 'wetting' from Earlier Post: Smoke
"...Chemical and biological oceanographers frequently analyze nutrient data with respect to the Redfield Ratios to determine which nutrient is the production-limiting nutrient. 

While Iron (Fe) is important in some regions, particularly open ocean regions distant from land--(where the Cortex is taken to be 'land' and the 'open ocean regions' serve as analogies to the ventricle system), in most productive regions the limiting nutrient is either Nitrogen (N) or Phosphorous (P)--here, the 'productive regions' being the more 'cultivated' brain areas, outside of the ventrical system. 

And while Calcium, Potassium and other trace metals in seawater contribute to thriving coral reefs, it has been demonstrated that enriched phosphate levels can significantly inhibit overall coral calcification and thereby adversely affect coral reef growth (see tau inclusions, hyperphosphorylation of tau proteins, above, and Coral Reef Health/Brain Analogy, earlier post 'Smoke', below). 

Correspondent to how the role Ca and K balance (and other trace minerals such as P and Fe, etc) contributes to thriving coral reefs in the Sea, clearly defined levels of Calcium and Potassium are closely linked to human health. Calcium is used for bone formation and cell signaling and disturbances in Sodium, Potassium and Calcium levels is typically more serious than for other minerals in humans. (Refer to Sign 75:3-75:4 regarding gathering bones + fingertips, below.)

The relationship between Calcium + Bones + Iron and its relevance to AD:

{May 2012 Excerpt from The Star Advisor

"What is this secret affair between Vitamin D and Iron?

When vitamin D status is assessed, a specific form of the vitamin is measured in the blood: 25-hydroxy vitamin D. It is produced primarily in the liver, where a slight alteration to vitamin D takes place. This essential step is required for vitamin D to have its beneficial functions in the body.

This is where the secret affair happens.(Hopefully this feeds Your appetite for a Scandal!) As it turns out, this chemical step requires Iron (Fe). Based on this known biochemistry, if iron status is low, the formation of 25-hydroxy vitamin D is likely to be impaired.

There is limited evidence that Iron (Fe) and vitamin D deficiencies frequently coexisted... giving vitamin D supplements to 6- to 24-month-old infants and toddlers proved of no benefit when the infants also were iron deficient. Vitamin D status only improved when supplemental Iron (Fe) was also given.

The fact that Iron is the most common nutrient deficiency in the United States...At the least, it seems that vitamin D researchers and physicians should be measuring indices of Iron status along with vitamin D."}

In many ways coral reefs in the Ocean are analogous to the brain in the Central Nervous System. And the manner in which trace metal cations such as Ca and K contribute to the health of the coral in the Ocean is analogous to the brain and its vulnerability to either a deficit or an excess of these trace metals, in effect '...So Below'. 

And by extension, a talented spectroscopist may be able to draw some conclusions pertaining to how these same cations Ca and K, including Fe, behave in quiet and 'flaring' (refer to Sign 18:96 above about the Fe reduction process and its reaching a blazin/flaring state, it may be an indication of the expected thermodynamics of the reaction, the heading Vitamin C above) areas of the human brain (perhaps the pia mater/arachnoid/dura mater) based on relationships observed in the Sun's photosphere/chromosphere/carona spectral profile for these same elements, to plumb for the 'As Above...' correlation. 

In the central nervous system, metallic cations are involved in oligodendrocyte maturation (see reference to Sign 18:96 and advanced/adult self-similars reference) (oligodendrocytes are cells that coat axons in the central nervous system with their cell membrane forming a specialized membrane differentiation called myelin, which factors in providing insulation to the axon allowing electrical signals to propagate more efficiently) and myelinogenesis (myelinogenesis is the sequential growth and maturation of myelin sheaths which enable brain signals (neural signals) to propagate faster and with less signal loss), and metallic cations have been associated with pathogenesis, particularly multiple sclerosis and malignant gliomas; severe human pathologies as yet without efficient treatments. 

Sign 57:25, may apply to these pathologies in that 57Fe is a minor stable Iron isotope which is closely associated with Mössbauer spectroscopy and the Iron-dependent enzyme RNR (ribonucleotide reductase is essential for DNA synthesis; or Rest And Relaxation, essential for averting insanity); in which case the 25 may be referring to 25–amino acid hepcidin (hepcidin 25). 

Myelin is considered a defining characteristic of the (gnathostome or jawed) vertebrates, and myelination a key developmental stage in the human brain ('white matter'), continuing for at least another 10 to 12 years after birth; the rate of development of these brain structures is linked to the rate of development of related brain functions. And it is this association between metal cations, myelinogenesis and brain development in vertebrates that distinguishes them from invertebrates (like insects and worms). 

The utilization of these cations (refer to tau inclusions and their self-assembly expected to be reversible due to non-covalent bonding, which infers electromagnetic interaction like that found in metal ionic bonding or hydrogen bonds, van der Waals forces, and hydrophobic interactions) in vertebrates and invertebrates differs at the most rudimentary levels. 

The Ca and K ions diffuse through cell membranes but Fe is relatively insoluble. Iron and Calcium are required in vast amounts for hemoglobin and bone formation in humans; this contrasts markedly with insects that require them in only trace amounts. And phytophagous insects need relatively large amounts of Potassium and only trace amounts of Sodium, whereas humans and other vertebrates need these same minerals in reverse order. 

Do AD patients present with some kind of anemia, is the Iron in hemoglobin somehow dissolving (oxidizing) and contributing to the overall deterioration of the brain?}

Back to the Alz River (central canal + cerebrospinal fluid), You Know, the one that originates or runs through the swamp land of Alder woods. The root comes from the Lithuanian 'red' or 'brown', there are direct associations between the alder trees and the description of AD.  Its flowers are catkins, the females (read: 'recipient') are shorter than the male (read: 'emitter') flowers, and are known to be 'woody' and do not 'disintegrate' on maturity.

Surah 27 An.naml (The Ants)  

27:44 So, He (Solomon) said to Her (The Queen of Sheba), "Enter/(Log In)/State/Bring Down/Cut Open/Profess/Say/Affirm 'True of False' the Palace/Tower/Edifice/Story," and upon seeing it She thought/deemed/calculated/estimated/cast==threw across/cipher==put into code/computed (it) a pool of water, (an) Abyss/free space/indefinite expanse/immeasurable deep, fathomless cavity or expanse and She uncovered/revealed/showed her legs/trunk/crus/drive(s)/var. reddish-brown clay (allusion to petrichor?); He said/declared, "(It's an) Edifice/Palace/Tower/Story Paved/Satellite?/Tiled/Covered/Surfaced/Protected (aisle/pathway/lane supported (Disciple) from/of Glass/Bottles/Warrior Forces===Competing Forces/Fighting Forces." She said, "My God (Sustainer/Supporter/Creator)! I've been wronging/lost/shadowing/shading/umbraged/ghosting/lie-ing to myself and I surrender/believe, as with Solomon , God (Allah) Is The Sustainer/Creator/Supporter (of) The Worlds!"

In a nutshell Solomon (pbuh, because I know He's more than a little InCENSCED!) informs the Queen of Sheba 'It's just a front of 'competing forces'...' (paraphrasing)

One would imagine that the mechanism that the flowers release their seed is akin to most conifers (hygromorphic), in that the difference in the rate of swelling between the interior and exterior portion of a pine cone scales causes them to open and shut depending on the humidity (environmental moisture/wetness/flooding).

Alder trees, with very few exceptions, are deciduous, with leaves that are simple, alternate and serrated. Serration is elemental in scrambling signals in the design of stealth aircraft. (The expected shape of the substances that play a central role in either AD or its cure is expected to have a molecular geometry or branching structure similar to alder leaves; simple, alternate, serrated?)

Geometry in Branching Structures of Evergreen Twigs
Alternate, Opposite, and Whoreld

Alder is known to be a 'pioneer species', due in large part to its symbiotic relationship to nitrogen-fixing bacteria which improves the 'fertility of the soil'. (Note:  Soil, Earth, any type of 'ground' is used to mean 'basis' or 'substrate' here.) The same category of bacteria responsible for the 'scent on a rainy day' aka 'petrichor', which is a type of oil released by plants and soil when it rains along with another compound 'geosmin' (read that one however You like, but it sounds like 'from the Earth' to me, See The Secret of Min).

The root for the word petrichor derives from the Greek petra for 'stone', and it appears the primary function of petrichor is to retard seed germination and early plant growth.

Surah 17 Al.Isra (The Night Journey, The Ascension)
قُل كُونُواْ حِجَارَةً أَوْ حَدِيدًا (17:50
17:50 Say, "Be you Stones or Iron"...(God Will and Can Resurrect you all)

A wikipedia article makes mention, factual or otherwise, that the scent just before the rain is associated with ozone and that during and after the rain, wet soil, is due to petrichor and geosmin.

These are real world models giving us:

1. the irritant for sensitization, (ie., ozone a known irritant), + 
2. a humectant in the form of an organic oil like petrichor as the agent that prolongs contact to deliver + 
3. the 'medicine' ~ bicyclic alcohol bound/associated with petrichor, that being geosmin.

One model for how the toxin/medicine is being delivered in a natural setting.

The real world model of the intermittent flooding of the ventricular system for this model of an AD treatment is conveniently given by the seasonal monsoons.

While these long rainy seasons travel throughout Southeast Asia, the summer monsoons providing 80% of the rainfall in India from June through September, and since the focus was on India due to its cuisine contributing turmeric and cinnamon to the anti-oxident, anti-inflammatory treatment of AD, it stands to reason that AD is less prevalent in Indian society because of the rains that bring with them a healthful dose of being exposed to a partial treatment/deterrent to developing AD.

Here we're guessing the monsoons (duration and cycles) model the delivery mechanism for the ozone+humectant+medicine that revives prone brain cells.

Yes, that's exactly right, eating curry and taking a walk in the rain may actually help fight Alzheimer's.

Why it works.

Recall: Quran As Knowledge Object

The utility of a knowledge object is to take each concept (here a Verse in the Quran pertaining to Old Age and the element Iron) independently and in the aggregate in order to develop a solution to a given problem.

This and the fact (that as I tried to set out to prove throughout) that fractals are characteristic of things perfected by Nature or Otherwise, so the Message of the Quran is expected to Scale Up (in the aggregate) and Down (when taken apart) accordingly and still make sense (See earlier Post At Six's and Sevens, As Above...So Below).

So taking the Signs pertaining to Iron Collectively, and applying the principles mentioned along with the present-day knowledge about the problem, the Signs should either stand up to Scrutiny by giving or leading to a workable solution--or, someone can tell me there is no God.

From the first guess on word-play alone the chemical CycloHexane is hypothesized (see above):
CycloHexane ---> Geosmin through the following associations:

Cyclohexane (C6H12) is sometimes used in cleaning products and contributes to their characteristic odor. It is used as a lab standard, a solvent and is commercially made by reacting Benzene with Hydrogen.

Benzene (C6H6) is an Aromatic Cyclic Hydrocarbon, (the ring is formed by the pi-bonds with Hydrogen which contribute to its resonance structure, ie;, the hydrogen is shared between the Carbons). Benzene is carcinogenic and is a predominant component of crude oil, (i.e.. it is a petrochemical--see petrichor above). Note: Benzene -->Napthalene; the fusion of 2 benzene rings forms the simplest polycyclic aromatic hydrocarbon Napthalene.

Decalin is DecahydroNapthalene. In the like manner as napthalene may be thought of as a fusion of 2 benzene rings, Decalin is the analogous fusion of 2 cyclohexane molecules. It is the saturated analog of napthalene and can be formed by hydrogenation of napthalene in the presence of a catalyst. It has cis and trans- isomers and according to a wikipedia article:

"...the trans configuration comes with a price: the only possible way to join the two six membered rings (cyclohexane) in the trans position means the second ring needs to start from the two equatorial bonds of the first ring. 

A six-membered ring does not offer sufficient space to start out on an axial position (upwards), and reach the axial position of the neighboring carbon atom, which then will be on the downwards side of the molecule. 

A second price to be paid is the effective freezing of the rings in a fixed conformation. 

In biology this fixation is widely used in the steroid skeleton to construct molecules that play a key role in the signaling between distantly separated cells. (that old 'spooky action at a distance' thing, again)"

{Note: The importance of equatorial bonds to this data blogger: The organic chemistry naming convention for Alpha and beta (α/β) is predominantly used in naming sugars and steroids and provides a useful way in identifying the orientation of the anomeric Oxygen. It is crucial in biochemistry, for example while cellulose (β-linked) and starch (α-linked) differ only in how the glucose subunits are linked together, humans can digest starch (α-linked) but not cellulose (β-linked).--That's right! If you show any signs of 'digesting' the veil of the mother of vinegar, then what can I say?--Houston, over_and_Ouch!

in order to apply α,β naming convention the sugar has be drawn in this specific orientation shown

When the sugar is drawn in the orientation as shown (carbons 1 through 5 follow a clockwise path), if the anomeric oxygen is UP (equatorial) it is “beta” (see carotene above + β-rings), and if it is “down” it is alpha (α-linked).}

Geosmin (C12H22O) is  a bicyclic alcohol and a chemical derivative of Decalin. It is produced by various microorganisms and contributes to the smell of petrichor. Under acidic conditions Geosmin's strong odor associated with wet soil and bottom feeding fish dissociates into odorless compounds.

  

CycloHexane

Benzene

Decalin

Geosmin

Surah 3 Al.3'mran (The Family 'Imran, Jesus' Lineage)
فَكَيْفَ إِذَا جَمَعْنَاهُمْ لِيَوْمٍ لاَّ رَيْبَ فِيهِ وَوُفِّيَتْ كُلُّ نَفْسٍ مَّا كَسَبَتْ وَهُمْ لاَ يُظْلَمُونَ (3:25
3:25) How would it be when We Gather them on a Day that there can be no evading, and each Soul will be fully paid what it earned, and they shall not be wronged (dealt with unjustly)?

Surah 4 Nissa (Women)
اللّهُ لا إِلَـهَ إِلاَّ هُوَ لَيَجْمَعَنَّكُمْ إِلَى يَوْمِ الْقِيَامَةِ
لاَ رَيْبَ فِيهِ وَمَنْ أَصْدَقُ مِنَ اللّهِ حَدِيثًا (  4:87
4:87) God, there is no other deity but for Him. He Will Gather you all on the Day of Judgment, there is not evading it. And What Is More Truthful than God's Words?

Surah 4 Nissa (Women)
لَّن يَسْتَنكِفَ الْمَسِيحُ أَن يَكُونَ عَبْداً لِّلّهِ وَلاَ الْمَلآئِكَةُ الْمُقَرَّبُونَ
 وَمَن يَسْتَنكِفْ عَنْ عِبَادَتِهِ وَيَسْتَكْبِرْ
 فَسَيَحْشُرُهُمْ إِلَيهِ جَمِيعًا (4:172
4:172) The Christ was never disdainful of Worshipping God, and neither the Angels Nearest (Dearest) to Him; and of whomever disdains of worshipping Him and is prideful, He Shall Gather them (all) unto Himself altogether.

Surah 6 Al.An3am (Cattle, Chattle, Possessions)
وَإِن كَانَ كَبُرَ عَلَيْكَ إِعْرَاضُهُمْ
فَإِنِ اسْتَطَعْتَ أَن تَبْتَغِيَ نَفَقًا فِي الأَرْضِ أَوْ سُلَّمًا فِي السَّمَاء فَتَأْتِيَهُم بِآيَةٍ
وَلَوْ شَاء اللّهُ لَجَمَعَهُمْ عَلَى الْهُدَى
 فَلاَ تَكُونَنَّ مِنَ الْجَاهِلِينَ (6:35
6:35) ...and If God Wills, He Would Gather them unto Guidance, so do not be of the childish (naive, immature).

Surah 45 Al.Jathiya (Kneeling) حم
قُلِ اللَّهُ يُحْيِيكُمْ ثُمَّ يُمِيتُكُمْ ثُمَّ يَجْمَعُكُمْ إِلَى يَوْمِ الْقِيَامَةِ
 لَا رَيبَ فِيهِ وَلَكِنَّ أَكَثَرَ النَّاسِ لَا يَعْلَمُونَ (45:26
45:26) Say, "God Revives you (Gives you Life) then Puts you to Death then Gathers you until/to Judgment Day; there is no evading it, yet most people (folk) are unaware."

Surah 50 Qaf ق
يَوْمَ تَشَقَّقُ الْأَرْضُ عَنْهُمْ سِرَاعًا
 ذَلِكَ حَشْرٌ عَلَيْنَا يَسِيرٌ (50:44
50:44) A Day the Earth splits/fissures about them quickly; then they are Gathered Unto Us Straightaway.

Surah 56 Al.Waqi3a (The Inevitable, Outcome, Event)
لَمَجْمُوعُونَ إِلَى مِيقَاتِ يَوْمٍ مَّعْلُومٍ (56:50
56:50) They will be Gathered on an appointed Day, well-known (to God).

Surah 77 Al.Mursalat (Messengers, Winds)
هَذَا يَوْمُ الْفَصْلِ جَمَعْنَاكُمْ وَالْأَوَّلِينَ (77:38
77:38) This is the Day of Disambiguation/Decision/Delineation..., We Gathered you and the Ancients (predecessors/forebears)


So, in the above example, we Gathered or Correlated the Signs mentioning the keyword IRON and Old Age, in order to decide how to go about finding a solution to a given problem, concerned with a way to treat/reverse Alzheimer's Disease. Since, I am not God, I cannot enliven or kill anyone, let alone make you all gather 'round, doing the same with His Signs is the extent to which I can model God's traits.

Argyle Sweater Comic Panel
'Chinese-to -English Dictionary'

BTW I didn't write the Quran--I'm just the interpreter...apparently someOne wanted to Read this version.

{"Where does She get off?!" They wonder.
Well, not with Steve H. (who BTW His wife is pregnant), but here:

Surah 75 Al.Qyama (The Resurrection)
أَيَحْسَبُ الْإِنسَانُ أَلَّن نَجْمَعَ عِظَامَهُ (75:3
بَلَى قَادِرِينَ عَلَى أَن نُّسَوِّيَ بَنَانَهُ (75:4

75:3) Does the Human figure that We Cannot Gather his Bones?
75:4) Assuredly, We Are Able to indeed Make/Assemble/Manufacture/Even his fingertips!

While this subject is of limited personal interest to me, AD runs in my children's father's family (maternal side), I would expect that the cure may or may not benefit us directly as my expectation is that my Son may already have the cure his father needs should AD present in his father, since they share very unique genetic markers that relate them as father and son outside the context of even a paternity test (my understanding is that it is father to son genetic marker, not even paternal uncles are as likely to have it, but their father (my son's paternal grandfather did). And since both the father and son also have the same blood type, it may be a serum can be developed in this isolated case, or even gene splicing, since they are so unique and, well, here's the Elephant in the Room argument. How's that for designer drugs.

Well, this is about as far as I can get with it and I am not a biochemist, or a medical researcher--I thought I was being asked to design a heat shield or some such thing...}

Since Your Absence is Palpable this evening, Gabriel (pbuh), I close this post with You In Mind:

Surah 55 Al-Rahman (The Beneficent)الرَّحْمَنُ 
55:1 الرَّحْمَنُ 
Alrrahman
55:1 The Beneficent;
عَلَّمَ الْقُرْآنَ (55:2
AAallama alquran
55:2 Taught the Qur’an,
خَلَقَ الْإِنسَانَ (55:3
Khalaqa alinsan
55:3 Created Man,
عَلَّمَهُ الْبَيَانَ (55:4
AAallamahu albayan
55:4 Taught him speech,
الشَّمْسُ وَالْقَمَرُ بِحُسْبَانٍ (55:5
Alshshamsu waalqamaru bihusbanin...

Surah 53 Al-Najm (The Star, Revelation, Unfolding)
وَأَنَّهُ هُوَ رَبُّ الشِّعْرَى (53:49 
Wa.innaHUa Rubbi al.Shi3'Ra

53:49) And Indeed, He Is the Sustainer of Sirius (The Lord of Ash.shi3'ra)

You don't much like my take on treatment for Alzheimer's Disease? You won't care for my cure for the common cold any better, I guarantee it. (Flatlander Fred's Experience)

{
Reported recently:

Neurology Research International
Volume 2012 (2012), Article ID 197438, 7 pages
doi:10.1155/2012/197438
Review Article
MRI Findings in Neuroferritinopathy

" It is also known that iron deposition increases normally with age...
...In patients with Alzheimer disease (AD), (excessive, my emphasis) iron deposition in neurons, neurofibrillary tangles, and plaques has been reported pathologically. To detect brain iron accumulation using MRI in AD... In these studies, increased iron levels were found in the basal ganglia..."

'Increased Fe levels in the basal ganglia reads like 'leaky gate' to me...}